doi: 10.3389/fendo.2022.846903 Received 31 December 2021 Accepted 01 February 2022 Published 21 February 2022 Volume 13 - 2022 Edited by Paolo Moghetti, University of Verona, Italy Reviewed by Flavia Prodam, University of Eastern Piedmont, Italy Updates Copyright 2022 Cignarelli, Genchi, Le Grazie, Caruso, Marrano, Biondi, DOria, Sorice, Natalicchio, Perrini, Laviola and Giorgino
More significant changes to established dark spots or melasma typically take eight to twelve weeks
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doi: 10.3389/fendo.2021.694284 36
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Peroxidase (POD, EC 1.11.1.7) activity was assayed using the guaiacol test where the enzyme activity is calculated as enzyme protein required for the formation of 1 mol tetraguaiacol min 1 (Chance and Maehly Citation1955)